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Tropomyosin receptor kinase B Wikipedia ~ Tropomyosin receptor kinase B TrkB also known as tyrosine receptor kinase B or BDNFNT3 growth factors receptor or neurotrophic tyrosine kinase receptor type 2 is a protein that in humans is encoded by the NTRK2 gene TrkB is a receptor for brainderived neurotrophic factor BDNF
TrkB Receptor an overview ScienceDirect Topics ~ TrkB receptors have been detected in nerve terminals axons and dendritic spines of glutamatergic pyramidal and granule cells in the hippocampus using a combination of light and electron microscopy Drake Milner Patterson 1999
Trk receptor Wikipedia ~ TrkB has the highest affinity to the binding of brainderived neurotrophic factor BDNF and is a growth factor that has important roles in the survival and function of neurons in the central nervous binding of BDNF to TrkB receptor causes many intracellular cascades to be activated which regulate neuronal development and plasticity longterm potentiation and apoptosis
TrkB Receptor Signalling Implications in ~ TrkB may in particular play an important role in the susceptibility to geriatric depression TrkB levels in the serum of clinically depressed patients are reported to be higher compared to that of the normal individuals Several TrkB mutations have been linked to the progression of anxiety disorders
AntiTrkB antibody ab18987 Abcam ~ Isoform TrkB is widely expressed mainly in the nervous tissue In the CNS expression is observed in the cerebral cortex hippocampus thalamus choroid plexus granular layer of the cerebellum brain stem and spinal cord
trkb SigmaAldrich ~ Search results for trkb at SigmaAldrich Summary This gene encodes a member of the neurotrophic tyrosine receptor kinase NTRK family
TrkB Wikipedia ~ Klein R et al 1990 The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain Cell 61 647656 Squinto SP et al 1991 trkB encodes a functional receptor for brainderived neurotrophic factor and neurotrophin3 but not nerve growth factor Cell 65 885893
NTRK2 BDNFNT3 growth factors receptor precursor Homo ~ Isoform TrkB is expressed in the central and peripheral nervous system In the central nervous system CNS expression is observed in the cerebral cortex hippocampus thalamus choroid plexus granular layer of the cerebellum brain stem and spinal cord
TRK Tocris Bioscience ~ Trk tropomyosinrelated kinase or neurotrophin receptors are single transmembrane catalytic receptors with intracellular tyrosine kinase activity Trk receptors are coupled to the Ras Cdc42RacRhoG MAPK PI3K and PLCγ signaling pathways There are four members of the Trk family TrkA TrkB TrkC and a related p75 NTR receptor p75 NTR lacks tyrosine kinase activity and signals via NFκB
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